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Background  We sought to identify gene polymorphisms that confer susceptibility to in-stent restenosis after coronary artery bare-metal stenting in a Central European population.    Methods  160 controls without post–percutaneous coronary intervention in-stent restenosis were matched for age, sex, vessel diameter, and diabetes to 160 consecutive cases involving in-stent restenosis of the target lesion within 12 months. Using real time polymerase chain reaction and melting-curve analysis, we detected 13 single-nucleotide polymorphisms in 11 candidate genes - rs1803274 ( BCHE  gene) ,  rs529038 ( ROS1 ), rs1050450 ( GPX1 ), rs1800849 ( UCP3 ), rs17216473 ( ALOX5AP ), rs7412, rs429358 ( ApoE ) ,  rs2228570 ( VDR ), rs7041, rs4588 ( GC ) ,  rs1799986 ( LRP1 ) and rs2228671 ( LDLR ) .  Multivariable logistic regression was used to test for associations.    Results  The rs1803274 polymorphism of  BCHE  was significantly associated with in-stent restenosis (OR 1.934; 95 % CI: 1.181–3.166;  p  = 0.009). No association was found with the other studied SNPs.    Conclusions  The A allele of rs1803274 represents a risk factor for in-stent restenosis in Central European patients after percutaneous coronary intervention with bare-metal stent implantation.

The rs1803274 polymorphism of the BCHE gene is associated with an increased risk of coronary in-stent restenosis