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Background  Collateral growth in patients with coronary artery disease (CAD) is highly heterogeneous. Although multiple factors are thought to play a role in collateral development, the contribution of genetic factors to coronary collateral circulation (CCC) is largely unknown. The goal of this study was to assess whether functional single nucleotide polymorphisms (SNPs) in genes involved in vascular growth are associated with CCC.    Methods  677 consecutive CAD patients were enrolled in the study and their CCC was assessed by the Rentrop method. 22 SNPs corresponding to 10 genes involved in postischemic neovascularization were genotyped and multivariate logistic regression models were adjusted using clinically relevant variables to estimate odds ratios and used to examine associations of allelic variants, genotypes and haplotypes with CCC.    Results  Statistical analysis showed that the  HIF1A  rs11549465 and rs2057482;  VEGFA  rs2010963, rs1570360, rs699947, rs3025039 and rs833061;  KDR  rs1870377, rs2305948 and rs2071559;  CCL2  rs1024611, rs1024610, rs2857657 and rs2857654;  NOS3  rs1799983;  ICAM1  rs5498 and rs3093030;  TGFB1  rs1800469;  CD53  rs6679497;  POSTN  rs3829365 and rs1028728; and  LGALS2  rs7291467 polymorphisms, as well as their haplotype combinations, were not associated with CCC (p < 0.05).    Conclusions  We could not validate in our cohort the association of the  NOS3  rs1799983,  HIF1A  rs11549465,  VEGFA  rs2010963 and rs699947, and  LGALS2  rs7291467 variants with CCC reported by other authors. A validated SNP-based genome-wide association study is required to identify polymorphisms influencing CCC.

bmc cardiovascular disorders

Genetic association study of coronary collateral circulation in patients with coronary artery disease using 22 single nucleotide polymorphisms corresponding to 10 genes involved in postischemic neovascularization