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Background  Postoperative pain after breast cancer surgery remains a major challenge in patient care. Local infiltration analgesia is a standard analgesic technique used for pain relief after surgery. Its application in patients who underwent mastectomy requires more clear elucidation. This study aimed to investigate the effect of ropivacaine infiltration of drainage exit site in ameliorating the postoperative pain after mastectomy.    Methods  A prospective randomized controlled study was conducted in 74 patients who were scheduled for unilateral mastectomy by standardized general anesthesia. Both intervention group and control group were given infiltration of the two entry points of drainage catheters with 10 ml 0.5% ropivacaine (Group A) ( n  = 37) or 10 ml normal saline (Group B) (n = 37). Pain scores were recorded in post-anesthesia care unit (PACU), at 6 h, 12 h, 24 h and 36 h after operation by using a visual analogue scale (VAS). Postoperative nausea and vomiting (PONV) incidence, postoperative analgesic and antiemetic requirements, the incidence of chronic pain, as well as the quality of recovery were recorded.    Results  The patients in Group A showed a significant reduction in postoperative pain in PACU ( p  < 0.0005), at 6 h ( p  < 0.0005), 12 h ( p  < 0.0005), and 24 h after surgery ( p  < 0.05) when compared to those in Group B. There were more postoperative analgesic requirements in Group B ( p  < 0.05). With regard to the quality of recovery, Group A was shown to be much superior over Group B ( p  < 0.05).    Conclusions  Ropivacaine infiltration of the two drainage exit sites decreased the degree of postoperative acute pain after mastectomy, and this approach improved patients’ quality of recovery.    Trial registration  retrospectively registered in  Chictr.org.cn  registry system on 24 February 2020 ( ChiCTR2000030139 ).

Ropivacaine infiltration analgesia of the drainage exit site enhanced analgesic effects after breast Cancer surgery: a randomized controlled trial