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Background  In clinical practice, the laryngeal mask airway is an easy-to-use supraglottic airway device. However, the  cis- atracurium dosage for laryngeal mask insertion has not been standardised. We aimed to determine the optimal dose of  cis- atracurium using a sequential method for successful laryngeal mask insertion.    Methods  The cohort study protocol is registered at  clinicaltrial.gov  (NCT-03668262). Twenty-three patients undergoing elective urinary surgery were sequentially administered  cis- atracurium doses as follows: 150, 100, 70, 50, 30, and 20 μg·kg − 1 . The main outcome involved the determination of the response to laryngeal mask airway insertion: ≥16 points and < 16 points indicated “satisfactory” and “unsatisfactory” responses, respectively. The median effective dose was estimated using the mean of the seven crossovers from “satisfactory” and “unsatisfactory” responses. The primary outcome involved the determination of the median effective dose (ED50) of  cis- atracurium for laryngeal mask airway insertion.    Results  The median effective dose of  cis- atracurium was 26.5 μg·kg − 1  (95% CI 23.6–29.8) using the sequential method. Heart rate was decreased in the 50 μg·kg − 1  group compared to that in the 30 μg·kg − 1  group at timepoints T7, T8, and T10 ( P  = 0.0482,  P  = 0.0460, and  P  = 0.0236, respectively), but no difference was observed in the 20 μg·kg − 1  group. Systolic blood pressure was decreased in the 50 μg·kg − 1  group compared to that in the 20 μg·kg − 1  group at timepoints T2, T3, and T4 ( P  = 0.0159,  P  = 0.0233, and  P  = 0.0428, respectively). The train-of-four value was significantly lower in the 50 μg·kg − 1  group than in the 30 μg·kg − 1  group at timepoint T3 ( P  = 0.0326).    Conclusions  The ED50 of  cis- atracurium was 26.5 μg·kg − 1  for laryngeal mask airway insertion.    Trial registration   Clinicaltrial.gov  Registry,  NCT03668262 , Registered on 11 September 2018.

bmc anesthesiology

The median effective dose (ED50) of cis-Atracurium for laryngeal mask airway insertion during general Anaesthesia for patients undergoing urinary surgery