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Background  Dexmedetomidine (DEX), a highly sensitive α 2 -adrenoceptor agonist that possesses anxiolytic, sedative, and analgesic effects, has been documented as a preventative and treatment for emergence agitation (EA). The therapeutic should be given as a loading dose that is infused during a 10 min period, but if a rapid bolus injection is deemed to be hemodynamically appropriate, it would be a more opportune route of administration. So we studied the efficacy of different doses of DEX as a rapid bolus for children to prevent and treat EA.    Methods  One hundred patients were enrolled and randomly divided into five groups: the control group (group D 1 ), the 0.25 μg/kg DEX group (group D 2 ), the 0.5 μg/kg DEX group (group D 3 ), the 0.75 μg/kg DEX group (group D 4 ), and the 1 μg/kg DEX group (group D 5 ). Heart rate (HR), mean blood pressure (MBP) and blood oxygen saturation (SaO 2 ) were recorded immediately before the study drug injection (baseline) and every minute for 5 min thereafter and at the time points of the skin cut and hernial sac pull. EA and pain were assessed in the post -anesthesia care unit, and any complementary medicine and adverse events were recorded too.    Results  The incidence of EA was significantly decreased in group D 4  and group D 5  compared with D 1 .All groups exhibited similar baseline HR and MBP. After administered, HR and MBP were significantly decreased in all DEX group compared with group D 1. In groups D 3 , D 4  and D 5 , the minimal HR was decreased significantly compared with the groups D 1  and duration time of minimal HR significantly prolonged in group D 5 , but no patient needed treatment. As the dosage increased, the recovery time was significantly prolonged. There were no significant differences in occurrence time of minimal HR, the incidence of complementary medicine and adverse events among groups.    Conclusion  Rapid intravenous injection (IV) bolus administration of 0.75 and 1.0 μg/kg of DEX could improve the recovery profile by reducing the incidence of EA in children. Although its use resulted in a transient decreases in HR and MBP, DEX was clinically well-tolerated in children.    Trial registration  No.  ChiCTR-IPR-17010658 . Registered 17 February 2017.

Efficacy of different doses of dexmedetomidine as a rapid bolus for children: a double-blind, prospective, randomized study