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Background  The present study aimed to compare the intravenous bolus effect of oxycodone and fentanyl on hemodynamic response after endotracheal intubation and postoperative pain in patients undergoing closed reduction of nasal bone fracture.    Methods  In this prospective randomized double-blinded study, 64 patients undergoing closed reduction of nasal bone fracture were randomized into one of two groups: the fentanyl group (Group F) or the oxycodone group (Group O). Each drug (fentanyl 2 mcg/kg in Group F and oxycodone 0.2 mg/kg in Group O) was administered prior to the induction of general anesthesia. Hemodynamic changes after endotracheal intubation and postoperative pain were then measured in both groups.    Results  There was no significant difference in the change in mean arterial pressure and heart rate between pre-induction and post-intubation in both Groups F and O ( P  > 0.05). Postoperative pain in Group O was milder than that in Group F ( P  < 0.001); however, time to awakening from the end of operation was shorter in Group F ( P  = 0.012).    Conclusion  In patients undergoing closed reduction of nasal bone fracture, oxycodone attenuates hemodynamic response to endotracheal intubation similar to fentanyl. However, oxycodone is more effective than fentanyl in improving postoperative pain.    Trial registration  Clinical Research Information Service (Trial registry number:  KCT0001153 ) on 3 July, 2014    Electronic supplementary material  The online version of this article (doi:10.1186/s12871-016-0279-x) contains supplementary material, which is available to authorized users.

bmc anesthesiology

Comparison of hemodynamic response to tracheal intubation and postoperative pain in patients undergoing closed reduction of nasal bone fracture under general anesthesia: a randomized controlled trial comparing fentanyl and oxycodone