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Background  Preeclampsia (PE) is a condition of high blood pressure that is usually concurrent with proteinuria in pregnancy. PE complicates the management of both maternal and fetal health and contributes to most adverse pregnancy outcomes, but the mechanism underlying the development of PE remains unclear. In this study, we performed a case-control study to compare the gut microbiota of PE ( n  = 26), abnormal placental growth (APG,  n  = 25) and healthy pregnant women ( n  = 28) and analyzed the potential pathogenic role of gut microbiota in PE progression.    Results  The clinical pathophysiological state did not affect the bacterial diversity, while the compositions of the gut microbiota were significantly altered in both the PE and APG groups compared with healthy pregnant women. At the phylum level,  TM7  was significantly increased in women with APG. Heterogeneity was observed at the genus level, especially in genera with positive LDA scores, suggesting the stage-dependent effect of gut microbiota on the development of PE. The beneficial bacterium  Lactobacillus  was markedly depleted in the PE and APG groups but was only correlated with blood pressure (BP) and proteinuria levels in the PE group. Two different bacterial taxa belonged to  Lactobacillus  showed different correlations (OTU255 and OTU784 were significantly related to PE and APG, respectively).    Conclusions  Our results indicated that shifts in the gut microbiota might occur from the early stages of the development of PE, which is of possible etiological and therapeutic importance.

Gut microbiota changes in preeclampsia, abnormal placental growth and healthy pregnant women