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Background  Recurrent tonsillitis is one of the most common otolaryngological disorders caused by cell-invading bacteria, such as  Streptococcus pyogenes (S. pyogenes)  and  Haemophilus influenzae . The aim of this study was to investigate the effect of antibacterial agents against cell-invading bacteria.    Methods  The intracellular invasion of Detroit 562 cells by five strains of nontypeable  Haemophilus influenzae  (NTHi) and four strains of  S. pyogenes  was investigated. The antibacterial agents used were garenoxacin (GRNX), clarithromycin (CAM), amoxicillin (AMPC), cefditoren pivoxil (CDTR-PI), and levofloxacin (LVFX).    Results  Both NTHi and  S. pyogenes  fully invaded Detroit 562 cells in 6 h and were less sensitive to CAM. GRNX, CAM, and LVFX were effective against bacteria invading the cells, but AMPC and CDTR-PI were not effective. GRNX was the most effective.    Conclusion  GRNX was the most effective agent against bacteria invading cells.

Effectiveness of antibacterial agents against cell-invading bacteria such as Streptococcus pyogenes and Haemophilus influenzae