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Background   Lactobacillus gasseri  OLL2809 can highly induce interleukin (IL)-12 production in immune cells. Even though beneficial properties of this strain for both humans and animals have been reported, the mechanism by which the bacteria induces the production of IL-12 in immune cells remains elusive. In this study, we investigated the mechanism of induction of IL-12 using a mouse macrophage cell line J774.1.    Results  Inhibition of phagocytosis of  L. gasseri  OLL2809, and myeloid differentiation factor 88 and Toll-like receptors (TLRs) 7 and 9 signalling attenuated IL-12 production in J774.1 cells. Total RNA and genomic DNA of  L. gasseri  OLL2809, when transferred to the J774.1 cells, also induced IL-12 production. The difference in the IL-12-inducing activity of  Lactobacilli  is attributed to the susceptibility to phagocytosis, but not to a difference in the total RNA and genomic DNA of each strain.    Conclusion  We concluded that total RNA and genomic DNA of phagocytosed  L. gasseri  OLL2809 induce IL-12 production in J774.1 cell via TLRs 7 and 9, and the high IL-12-inducing activity of  L. gasseri  OLL2809 is due to its greater susceptibility to phagocytosis.

bmc microbiology

Total RNA and genomic DNA of Lactobacillus gasseri OLL2809 induce interleukin-12 production in the mouse macrophage cell line J774.1 via toll-like receptors 7 and 9