English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background   Acinetobacter baumannii  is one of the most important opportunistic pathogens responsible for hospital acquired infections. It displays multi-drug resistance profile and has the ability to colonize surfaces and persist under harsh conditions.  A. baumannii  two-component signal transduction system BfmRS, consisting of response regulator BfmR and sensor kinase BfmS, has been implicated in the control of various virulence-related traits and has been suggested to act as a global modulator of  A. baumannii  physiology.    Results  Here, we assessed the role of BfmR regulator in pellicle formation and bacterial competition, features important for the establishment of  A. baumannii  in clinical environment. We show that BfmR is required for the pellicle formation of  A. baumannii , as  ΔbfmRS  mutant lacked this phenotype. The loss of  bfmRS  also greatly reduced the secretion of  A. baumannii  Hcp protein, which is a component of T6SS secretion system. However, T6SS-mediated killing phenotype was not impaired in  ΔbfmRS  mutant. On the contrary, the same mutation resulted in the transcriptional activation of contact-dependent inhibition (CDI) system, which  A. baumannii  used to inhibit the growth of another clinical  A. baumannii  strain and a closely related species  Acinetobacter baylyi .    Conclusions  The obtained results indicate that BfmR is not only required for the pellicle phenotype induction in  A. baumannii , but also, due to the down-regulation of a CDI system, could allow the incorporation of other  A. baumannii  strains or related species, possibly increasing the likelihood of the pathogens’ survival.

The role of Acinetobacter baumannii response regulator BfmR in pellicle formation and competitiveness via contact-dependent inhibition system