English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background   Staphylococcus aureus  is a leading cause of Gram-positive bacterial infections worldwide; however, the treatment of  S. aureus  infection has become increasingly difficult due to the prevalence of methicillin-resistant  S. aureus  strains, highlighting the urgent need for the development of novel strategies. The complexity of  S. aureus  pathogenesis relies on virulence factors. Recent studies have demonstrated that leukocidins expressed by the majority of clinical isolates play important roles in the pathogenesis of  S. aureus .    Results  In this study, we developed three human monoclonal antibodies against all F-components of leukocidins HlgABC, LukSF, and LukED with high affinity. These antibodies were found to be capable of blocking leukocidin-mediated cell lysis in vitro. Furthermore, the antibodies dramatically reduced disease progression and mortality after  S. aureus  infection in vivo.    Conclusions  Our findings revealed that neutralizing bicomponent leukocidins may be a promising strategy to combat infections caused by  S. aureus.Electronic supplementary material  The online version of this article (10.1186/s12866-018-1312-7) contains supplementary material, which is available to authorized users.

Novel human monoclonal antibodies targeting the F subunit of leukocidins reduce disease progression and mortality caused by Staphylococcus aureus