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Background  Asthma, one of the most common chronic respiratory disorders, is associated with the hyper-activation of the T-cell subset of adaptive immunity. The gut microbiota may be involved in the development of asthma through the production of short-chain fatty acids (SCFAs), exhibiting modulatory effects on Th. So, we performed a metagenome-wide association study (MWAS) of the fecal microbiota from individuals with asthma and healthy controls. And that was the first case to resolve the relationship between asthma and microbiome among UK adults.    Results  The microbiota of the individuals with asthma consisted of fewer microbial entities than the microbiota of healthy individuals.  Faecalibacterium prausnitzii ,  Sutterella wadsworthensis  and  Bacteroides stercoris  were depleted in cases, whereas  Clostridiums  with  Eggerthella lenta  were over-represented in individuals with asthma. Functional analysis shows that the SCFAs might be altered in the microbiota of asthma patients.    Conclusion  In all, the adult human gut microbiome of asthma patients is clearly different from healthy controls. The functional and taxa results showed that the change of asthma patients might related to SCFAs.    Electronic supplementary material  The online version of this article (10.1186/s12866-018-1257-x) contains supplementary material, which is available to authorized users.

A metagenome-wide association study of gut microbiota in asthma in UK adults