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Background  Acute gastroenteritis is a common cause of morbidity and mortality in humans worldwide. The rapid and specific identification of infectious agents is crucial for correct patient management. However, diagnosis of acute gastroenteritis is usually performed with diagnostic panels that include only a few pathogens. In the present bicentric study, the diagnostic value of FilmArray™ GI panels was assessed in unformed stool samples of patients with acute gastroenteritis and in a series of samples collected from pediatric patients with heamorragic diarrhea. The clinical performance of the FilmArray™ gastrointestinal (GI) panel was assessed in 168 stool samples collected from patients with either acute gastroenteritis or hemorragic diarrhea. Samples showing discordant results between FilmArray and routine methods were further analyzed with an additional assay.    Results  Overall, the FilmArray™ GI panel detected at least one potential pathogen in 92/168 (54.8%) specimens. In 66/92 (71.8%) samples, only one pathogen was detected, while in 26/92 (28.2%) multiple pathogens were detected.  The most frequent pathogens were rotavirus 13.9% (22/168),  Campylobacter  10.7% (18/168),  Clostridium difficile  9.5% (16/168), and norovirus 8.9% (15/168).  Clostridium difficile  was identified only in patients with acute gastroenteritis ( p  &lt; 0.01), while STEC was detected exclusively in patients with hemorragic diarrhea ( p  &lt; 0.01). In addition,  Campylobacter spp., Salmonella spp.,  EPEC and  E. coli  producing Shiga-like toxin were more frequently detected in patients with hemorragic diarrhea ( p  &lt; 0.05). The overall percent agreement calculated in samples was 73.8% and 65.5%, while 34.5% were discordant. After additional confirmatory analyses, the proportion of discordant samples decreased to 7.7%. Rotavirus and astrovirus were the most frequently unconfirmed pathogens.    Conclusion  In conclusion, the FilmArray™ GI panel has proved to be a valuable new diagnostic tool for improving the diagnostic efficiency of GI pathogens.

FilmArray™ GI panel performance for the diagnosis of acute gastroenteritis or hemorragic diarrhea