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Background  Wound-related infection remains a major challenge for health professionals. One disadvantage in conventional antibiotics is their inability to penetrate biofilms, the main protective strategy for bacteria to evade irradiation. Previously, we have shown that synthetic antimicrobial peptides could inhibit bacterial biofilms formation.    Results  In this study, we first delineated how Nal-P-113, a novel antimicrobial peptide, exerted its inhibitory effects on  Porphyromonas gingivalis  W83 biofilms formation at a low concentration. Secondly, we performed gene expression profiling and validated that Nal-P-113 at a low dose significantly down-regulated genes related to mobile and extrachromosomal element functions, transport and binding proteins in  Porphyromonas gingivalis  W83.    Conclusions  These findings suggest that Nal-P-113 at low dose is sufficient to inhibit the formation of biofilms although  Porphyromonas gingivalis  W83 may maintain its survival in the oral cavity. The newly discovered molecular pathways may add the knowledge of developing a new strategy to target bacterial infections in combination with current first-line treatment in periodontitis.    Electronic supplementary material  The online version of this article (doi:10.1186/s12866-017-0948-z) contains supplementary material, which is available to authorized users.

bmc microbiology

Molecular pathways underlying inhibitory effect of antimicrobial peptide Nal-P-113 on bacteria biofilms formation of Porphyromonas gingivalis W83 by DNA microarray