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Background  Haemophili are representative microbiota of the upper respiratory tract. The aim of this study was to assess the effects of perioperative antimicrobial prophylaxis and/or postoperative treatment on  Haemophilus parainfluenzae  prevalence, and antimicrobial sensitivity in short-term hospitalized patients with lung cancer who underwent surgery.    Results  Samples were collected from 30 short-term hospitalized patients with lung cancer and from 65 healthy people. The nasal and throat specimens were taken twice from each patient: before (EI, Examination I), on the fourth/fifth day (EII, Examination II) after surgery, and once from healthy people. The isolates identification and antimicrobial susceptibility were detected by routine diagnostic methods.  H. parainfluenzae  was found in throat specimens of 42/65 (64.6 %) healthy people, while in 19/30 (63.3 %) lung cancer patients in EI ( p  = 0.6203) and in 13/30 (43.3 %) ones in EII ( p  = 0.0106). Neither the disease itself nor short-term hospitalization with perioperative prophylaxis alone affected  H. parainfluenzae  prevalence in EII, while perioperative prophylaxis with postoperative treatment significantly decreased its colonization in EII. The differences in the number of patients colonized by  Candida  spp. in EI and in EII were observed ( p  = 0.0082).Totally, 23/58 (39.7 %) of  H. parainfluenzae  isolates were resistant mainly to beta-lactams; among 11 ampicillin-resistant isolates only 3 were beta-lactamase positive.    Conclusions  The antimicrobial perioperative prophylaxis together with postoperative treatment may disturb the composition of the airways microbiota represented by  H. parainfluenzae , in addition to selecting the resistant strains of bacteria and promoting yeasts colonization in lung cancer patients undergoing surgery.

bmc microbiology

Haemophilus parainfluenzae as a marker of the upper respiratory tract microbiota changes under the influence of preoperative prophylaxis with or without postoperative treatment in patients with lung cancer