English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Background   S. aureus  is an important agent of colonization and infection in liver transplant patients. It harbors several virulence factors that can increase its pathogenicity. However, studies of virulence and molecular typing of MRSA in cirrhotic and liver transplantation patients are scarce.    Results  Here we use SCC mec , PFGE,  spa  typing, MLST and virulence factors to characterize MRSA isolates in pre and post liver transplantation patients. Sixteen (13 %) of 126 cirrhotic and 15 of the 64 liver-transplanted patients (23 %) were colonized by MRSA ( p  = 0.091). SCC mec  types I, II and III that are generally associated with nosocomial infections were identified in 91 % of the isolates. None of the isolates carried PVL, adhesion factors and  fi b gene. Only three MRSA colonized isolates carried  tst  gene and were characterized as SCC mec  type I and t149. Ten  spa  types and five STs were identified; t002 and ST105 were the most frequent profiles.  Spa  types and ST1510 never described in Brazil and a new  spa  type t14789 were identified. Nineteen PFGE subtypes were found and grouped into nine types. There was a predominant cluster, which was related to the New York/Japanese epidemic clone and harboured SCC mec  type II identified in both cirrhotic and post-transplantation patients. Based on SCC mec  and virulence factors the MRSA isolates belonged to NY/Jpn clone seen be more similar to the USA100 MRSA isolates.    Conclusions  Although without significance, liver-transplantation was more frequently colonized by MRSA than cirrhotic patients. The most frequent SCC mec  was type II, and the predominant cluster was related to the New York/Japanese clone. A new  spa  t14789, and ST1510 never reported in Brazil were identified.

bmc microbiology

Staphylococcus aureus isolates colonizing and infecting cirrhotic and liver-transplantation patients: comparison of molecular typing and virulence factors