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Background  Fra-1 (fosl1) belongs to the activator protein1 (AP-1) family inducing  IL-11  expression in oxidative stress condition. IL-11 plays a pivotal role in protecting epithelial barriers integrity. In this study, we investigated the  Fra-1  gene expression in the inflamed mucosa of patients with ulcerative colitis (UC) as well as its relation to IL-11 expression.    Materials and methods  We enrolled 20 patients and 20 healthy controls with definite UC based on the clinical criteria.  Fra-1  gene expression in inflamed and non-inflamed colonic biopsies was determined by real-time polymerase chain reaction (RT-PCR). The IL-11 protein concentration was measured by Enzyme-Linked Immunosorbent Assay (ELISA) method. Pearson correlation was applied to calculate the relation between Fra-1 and IL-11.    Results  An increased level of  Fra-1  gene expression was observed in patients with mild ulcerative colitis. The protein concentration of IL-11 was also increased in mild UC patients. Conversely, a significant decrease of IL-11 protein level was detected in severe UC patients compared to control group.    Conclusion  Oxidative stress in inflamed intestinal biopsies can induce  fra -1 gene expression. Our findings suggest that Fra-1 transcription factor leads to the production of IL-11 protein in UC patients.

The expression analysis of Fra-1 gene and IL-11 protein in Iranian patients with ulcerative colitis