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Background Ophiorrhiza pumila  (Rubiaceae) is capable of producing camptothecin (CPT), one monoterpene indole alkaloid extensively employed in the treatment of multiple cancers. Transcription factors (TFs)  GATA  are a group of transcription regulators involved in plant development and metabolism, and show the feature of binding to the GATA motif within the promoters of target genes. However,  GATA  TFs have not been characterized in  O. pumila . Result In this study, a total of 18  GATA  genes classified into four subfamilies were identified, which randomly distributed on 11 chromosomes of  O. pumila . Synteny analysis of GATA genes between  O. pumila  and other plant species such as  Arabidopsis thaliana ,  Oryza sativa ,  Glycine max ,  Solanum lycopersicum ,  Vitis vinifera , and  Catharanthus roseus  genomes were analyzed. Tissue expression pattern revealed that  OpGATA1  and  OpGATA18  were found to be correlated with  ASA ,  MK ,  CPR  and  GPPS,  which were highly expressed in leaves.  OpGATA7 , showed high expression in roots as most of the CPT biosynthetic pathway genes did, suggesting that these  OpGATAs  may be potential candidates regulating CPT biosynthesis in  O. pumila . Conclusions In this study, we systematically analyzed the OpGATA TFs, and provided insights into the involvement of OpGATA TFs from  O. pumila  in CPT biosynthesis.

Genome-wide survey of the GATA gene family in camptothecin-producing plant Ophiorrhiza pumila