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Background  Epigenetic modifications including DNA methylation and post-translational modifications of histones are known to regulate gene expression. Antagonistic activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs) mediate transcriptional reprogramming during insect development as shown in  Drosophila melanogaster  and other insects. Juvenile hormones (JH) play vital roles in the regulation of growth, development, metamorphosis, reproduction and other physiological processes. However, our current understanding of epigenetic regulation of JH action is still limited. Hence, we studied the role of CREB binding protein (CBP, contains HAT domain) and Trichostatin A (TSA, HDAC inhibitor) on JH action.    Results  Exposure of  Tribolium castaneum  cells (TcA cells) to JH or TSA caused an increase in expression of  Kr-h1  (a known JH-response gene) and 31 or 698 other genes respectively. Knockdown of the gene coding for CBP caused a decrease in the expression of 456 genes including  Kr-h1 . Interestingly, the expression of several genes coding for transcription factors, nuclear receptors, P450 and fatty acid synthase family members that are known to mediate JH action were affected by CBP knockdown or TSA treatment.    Conclusions  These data suggest that acetylation and deacetylation mediated by HATs and HDACs play an important role in JH action.    Electronic supplementary material  The online version of this article (10.1186/s12864-018-5323-4) contains supplementary material, which is available to authorized users.

Epigenetic modifications acetylation and deacetylation play important roles in juvenile hormone action