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Backgrounds   Macaca fascicularis  ( M. fascicularis ) is a primate model organism that played important role in studying human health. It is vital to better understand the similarity and differences of gene regulation between  M. fascicularis  and human. Current comparative study of gene regulation between the two species are limited by low quality of gene annotation and lack of regulatory element data on  M. fascicularis  genome.    Results  In this study, we improved the  M. fascicularis  gene annotation with 57 gene expression data from multiple tissues and, more importantly, a manual curation procedure. The new annotation enabled us to map gene expression and identify gene location more accurately.    Conclusions  Comparing with human gene expression data from the same cell types, we characterized the evolution of expression patterns of homologous genes.    Electronic supplementary material  The online version of this article (10.1186/s12864-018-5183-y) contains supplementary material, which is available to authorized users.

Improved Macaca fascicularis gene annotation reveals evolution of gene expression profiles in multiple tissues