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Background  The mangrove killifish  Kryptolebias marmoratus  is the only vertebrate that reproduces by self-fertilizing and is an important model species in genetics and marine ecotoxicology. Using whole-genome and transcriptome sequences, we identified all members of the cytochrome P450 (CYP) family in this model teleost and compared them with those of other teleosts.    Results  A total of 74 cytochrome P450 genes and one pseudogene were identified in  K. marmoratus . Phylogenetic analysis indicated that the  CYP  genes in clan 2 were most expanded, while synteny analysis with other species showed orthologous relationships of CYP subfamilies among teleosts. In addition to the  CYP2K  expansions, five tandem duplicated gene copies of  CYP5A  were observed. These features were unique to  K. marmoratus .    Conclusions  These results shed a light on  CYP  gene evolution, particularly the co-localized CYP2K, CYP5A, and CYP46A subfamilies in fish. Future studies of  CYP  expression could identify specific endogenous and exogenous environmental factors that triggered the evolution of tandem  CYP  duplication in  K. marmoratus .    Electronic supplementary material  The online version of this article (10.1186/s12864-017-4410-2) contains supplementary material, which is available to authorized users.

bmc genomics

Identification of 74 cytochrome P450 genes and co-localized cytochrome P450 genes of the CYP2K, CYP5A, and CYP46A subfamilies in the mangrove killifish Kryptolebias marmoratus