English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background   P. aeruginosa  is one of the top three causes of opportunistic human bacterial infections. The remarkable variability in the clinical outcomes of this infection is thought to be associated with genetic predisposition. However, the genes underlying host susceptibility to  P. aeruginosa  infection are still largely unknown.    Results  As a step towards mapping these genes, we applied a genome wide linkage analysis approach to a mouse model. A large F2 intercross population, obtained by mating  P. aeruginosa -resistant C3H/HeOuJ, and susceptible A/J mice, was used for quantitative trait locus (QTL) mapping .  The F2 progenies were challenged with a  P. aeruginosa  clinical strain and monitored for the survival time up to 7 days post-infection, as a disease phenotype associated trait. Selected phenotypic extremes of the F2 distribution were genotyped with high-density single nucleotide polymorphic (SNP) markers, and subsequently QTL analysis was performed. A significant locus was mapped on chromosome 6 and was named  P  .   aeruginosa   infection   resistance   locus  1 ( Pairl 1). The most promising candidate genes, including  Dok1, Tacr1, Cd207, Clec4f, Gp9, Gata2, Foxp1 , are related to pathogen sensing, neutrophils and macrophages recruitment and inflammatory processes.    Conclusions  We propose a set of genes involved in the pathogenesis of  P. aeruginosa  infection that may be explored to complement human studies.    Electronic supplementary material  The online version of this article (doi:10.1186/s12864-016-2676-4) contains supplementary material, which is available to authorized users.

Mapping genetic determinants of host susceptibility to Pseudomonas aeruginosa lung infection in mice