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Background  Undernutrition is an increasingly common problem. Insufficient calorie intake and nutrient deficiencies during pregnancy may have an impact not only on the mother, but may also alter metabolism in the infant. In this study, we have applied a calorie-restricted diet during gestation and examined its effect on hepatic  Fasn  mRNA and DNA methylation profiles in rats and their female progeny. The body composition and blood lipid profiles were also evaluated in both generations.    Results  The results showed that the investigated diet regimen exerted a greater effect on the dams than on the offspring. We found that, in the calorie-restricted group, the transcript level of the  Fasn  gene in the liver increased in the mothers, while in the progeny it was only slightly enhanced. The implemented diet altered lipid profile in the dams by decreasing total cholesterol, HDL, and TG levels. An increase in LDL was noted in the offspring. No change in DNA methylation profile was observed in response to the calorie-restricted diet.    Conclusions  Calorie restriction during pregnancy modified the hepatic  Fasn  mRNA transcript level and altered the blood cholesterol concentrations in dams, but there were no such effects in their four-week-old offspring. The examined dietary regimen had no effect on DNA methylation of the  Fasn  5′-flanking region in the rat liver.    Electronic supplementary material  The online version of this article (doi:10.1186/s12863-017-0544-0) contains supplementary material, which is available to authorized users.

Prenatal caloric restriction alters lipid metabolism but not hepatic Fasn gene expression and methylation profiles in rats