English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Using a genome-wide association study strategy, our previous study discovered 19 significant single-nucleotide polymorphisms (SNPs) related to semen production traits in Chinese Holstein bulls. Among them, three SNPs were within or close to the  phosphodiesterase 3A  ( PDE3A ),  membrane associated ring-CH-type finger 1  ( MARCH1 ) and  platelet derived growth factor receptor beta  ( PDGFRB ) genes. The present study was designed with the objectives of identifying genetic polymorphism of the  PDE3A ,  PDGFRB  and  MARCH1  genes and their effects on semen production traits in a Holstein bull population.    Results  A total of 20 SNPs were detected and genotyped in 730 bulls. Association analyses using de-regressed estimated breeding values of each semen production trait revealed four statistically significant SNPs for one or more semen production traits ( P  < 0.05): one SNP was located downstream of  PDGFRB  and three SNPs were located in the promoter of  MARCH1 . Interestingly, for  MARCH1 , haplotype-based analysis revealed significant associations of haplotypes with semen volume per ejaculate. Furthermore, high expression of the  MARCH1  gene was observed in sperm cells. One SNP (rs43445726) in the regulatory region of  MARCH1  had a significant effect on gene expression.    Conclusion  Our study demonstrated the significant associations of genetic variants of the  PDGFRB  and  MARCH1  genes with semen production traits. The identified SNPs may serve as genetic markers to optimize breeding programs for semen production traits in Holstein bull populations.    Electronic supplementary material  The online version of this article (doi:10.1186/s12863-017-0527-1) contains supplementary material, which is available to authorized users.

Genetic effects of PDGFRB and MARCH1 identified in GWAS revealing strong associations with semen production traits in Chinese Holstein bulls