English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Groupers ( Epinephelus  spp.) have been widely cultivated in China and South-East Asian countries. As a novel hybrid offspring crossed between  E. fuscogutatus ♀ and  E. lanceolatus ♂, Hulong grouper exhibits significant growth superiority over its female parent, which made it a promising farmed species in grouper aquaculture industry in China. Hulong grouper present a good combination of beneficial traits from both parent species, but the molecular mechanisms of its heterosis still remain poorly understood.    Results  Based on RNA sequencing and gene expression profiling, we conducted comparative transcriptome analyses between Hulong grouper and its parents  E. fuscoguttatus & E. lanceolatus . Six hundred sixty-two and 5239 differentially expressed genes (DEGs) were identified in the brains and livers, respectively. GO enrichment analysis of these DEGs revealed that metabolic process and catalytic activity were the most enriched GO terms. Further analysis showed the expressions of  GnRH1 and  GnRH3  in the brain, and GH/IGF axis related genes such as  IGF-1 ,  IGF-2b ,  IGFBP-1 ,  IGFBP-2 ,  IGFBP-4  and  IGFBP-5a  in the liver of the hybrid F1 were significantly up-regulated, which is in accordance with the growth superiority of hybrid grouper. Meanwhile, expressions of genes related to the protein and glycogen synthesis pathway, such as  PI3KC ,  PI3KR ,  Raptor ,  EIF4E3 , and  PP1  were up-regulated, while  PYG  expression was down-regulated. These changes might contribute to increased protein and glycogen synthesis in the hybrid grouper.    Conclusions  We identified a number of differentially expressed genes such as  GnRH1  and  GnRH3 , and genes involved in GH/IGF axis and its downstream signaling pathways for protein and glycogen synthesis in Hulong Grouper. These findings provided molecular basis underlying growth superiority of hybrid grouper, and comprehensive insights into better understanding the molecular mechanisms and regulative pathways regulating heterosis in fish.    Electronic supplementary material  The online version of this article (doi:10.1186/s12863-016-0328-y) contains supplementary material, which is available to authorized users.

bmc genomic data

Transcriptome analysis reveals the molecular mechanisms underlying growth superiority in a novel grouper hybrid (Epinephelus fuscogutatus♀ × E. lanceolatus♂)