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Background  Primitive endoderm is a cell lineage segregated from the epiblast in the blastocyst and gives rise to parietal and visceral endoderm.  Sox7  is a member of the SoxF gene family that is specifically expressed in primitive endoderm in the late blastocyst, although its function in this cell lineage remains unclear.    Results  Here we characterize the function of  Sox7  in primitive endoderm differentiation using mouse embryonic stem (ES) cells as a model system. We show that ectopic expression of  Sox7  in ES cells has a marginal effect on triggering differentiation into primitive endoderm-like cells. We also show that targeted disruption of  Sox7  in ES cells does not affect differentiation into primitive endoderm cells in embryoid body formation as well as by forced expression of  Gata6 .    Conclusions  These data indicate that  Sox7  function is supplementary and not essential for this differentiation from ES cells.    Electronic supplementary material  The online version of this article (doi:10.1186/s12861-015-0079-4) contains supplementary material, which is available to authorized users.

Sox7 is dispensable for primitive endoderm differentiation from mouse ES cells