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Background  Logic Learning Machine (LLM) is an innovative method of supervised analysis capable of constructing models based on simple and intelligible rules.  In this investigation the performance of LLM in classifying patients with cancer was evaluated using a set of eight publicly available gene expression databases for cancer diagnosis.  LLM accuracy was assessed by summary ROC curve ( sROC ) analysis and estimated by the area under an  sROC  curve ( sAUC ). Its performance was compared in cross validation with that of standard supervised methods, namely: decision tree, artificial neural network, support vector machine (SVM) and  k -nearest neighbor classifier.    Results  LLM showed an excellent accuracy ( sAUC  = 0.99, 95% CI : 0.98–1.0) and outperformed any other method except SVM.    Conclusions  LLM is a new powerful tool for the analysis of gene expression data for cancer diagnosis. Simple rules generated by LLM could contribute to a better understanding of cancer biology, potentially addressing therapeutic approaches.

Analyzing gene expression data for pediatric and adult cancer diagnosis using logic learning machine and standard supervised methods