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Background  In ecology and forensics, some population assignment techniques use molecular markers to assign individuals to known groups. However, assigning individuals to known populations can be difficult if the level of genetic differentiation among populations is small. Most assignment studies handle independent markers, often by pruning markers in Linkage Disequilibrium (LD), ignoring the information contained in the correlation among markers due to LD.    Results  To improve the accuracy of population assignment, we present an algorithm, implemented in the  HaploPOP  software, that combines markers into haplotypes, without requiring independence. The algorithm is based on the Gain of Informativeness for Assignment that provides a measure to decide if a pair of markers should be combined into haplotypes, or not, in order to improve assignment. Because complete exploration of all possible solutions for constructing haplotypes is computationally prohibitive, our approach uses a greedy algorithm based on windows of fixed sizes. We evaluate the performance of  HaploPOP  to assign individuals to populations using a split-validation approach. We investigate both simulated SNPs data and dense genotype data from individuals from Spain and Portugal.    Conclusions  Our results show that constructing haplotypes with  HaploPOP  can substantially reduce assignment error. The  HaploPOP  software is freely available as a command-line software at  www.ieg.uu.se/Jakobsson/software/HaploPOP/ .

HaploPOP: a software that improves population assignment by combining markers into haplotypes