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Background  In France, two main diseases threaten Pacific oyster production. Since 2008,  Crassostrea gigas  spat have suffered massive losses due to the ostreid herpesvirus OsHV-1, and since 2012, significant mortalities in commercial-size adults have been related to infection by the bacterium  Vibrio aestuarianus . The genetic basis for resistance to  V. aestuarianus  and OsHV-1 and the nature of the genetic correlation between these two traits were investigated by using 20 half-sib sire families, each containing two full-sib families. For each disease, controlled infectious challenges were conducted using naïve oysters that were 3 to 26 months old. In addition, siblings were tested under field, pond and raceway conditions to determine whether laboratory trials reflected mortality events that occur in the oyster industry.    Results  First, we estimated the genetic basis of resistance to  V. aestuarianus  in  C. gigas . Susceptibility to the infection was low for oysters in spat stage but increased with later life stages. Second, we confirmed a strong genetic basis of resistance to OsHV-1 infection at early stages and demonstrated that it was also strong at later stages. Most families had increased resistance to OsHV-1 infection from the spat to adult stages, while others consistently showed low or high mortality rates related to OsHV-1 infection, regardless of the life stage. Our third main finding was the absence of genetic correlations between resistance to OsHV-1 infection and resistance to  V. aestuarianus  infection.    Conclusions  Selective breeding to enhance resistance to OsHV-1 infection could be achieved through selective breeding at early stages and would not affect resistance to  V. aestuarianus  infection. However, our results suggest that the potential to select for improved resistance to  V. aestuarianus  is lower. Selection for dual resistance to OsHV-1 and  V. aestuarianus  infection in  C. gigas  might reduce the impact of these two major diseases by selecting families that have the highest breeding values for resistance to both diseases.    Electronic supplementary material  The online version of this article (doi:10.1186/s12711-017-0297-2) contains supplementary material, which is available to authorized users.

genetics selection evolution

Genetic parameters of resistance to Vibrio aestuarianus, and OsHV-1 infections in the Pacific oyster, Crassostrea gigas, at three different life stages