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To the Editor. Drug-induced ectropion is a rare condition secondary to drug hypersensitivity. It was reported following administration of topical and systemic medications [1–7]. Among topical drugs, anti-glaucoma medications were the most reported drugs causing periorbital dermatitis and ectropion; however, other topical agents such as topical 5% fluorouracil cream and topical Tretinoin were described in the literature [4, 5]. Early cessation of offending medication was mentioned as the most important prognostic factor to reverse this complication without surgical intervention in previous studies [8]. Topical 5% Natamycin is the empirical topical medication for the treatment of fungal keratitis [9]. We reported drug-induced ectropion following chronic use of Natamycin in this study. To the best of our knowledge, there was no study in the literature reporting ectropion as a complication of Natamycin.

Drug-induced ectropion following the chronic use of topical Natamycin