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This paper reviews the many criticisms of the publication by Seralini et al (2012) which has led to so much controversy, was retracted and then republished in this journal. Seralini et al found that a GM maize and its associated herbicide Roundup resulted in numerous chronic abnormalities in rats. The vehemence of the critics is not matched by their evidence; it is often based on entrenched assumptions and on mis-representing published material. The arguments have challenged normal healthy scientific dialogue, and appear to be driven by other motives. A further interpretation of Seralini et al's results on tumour formation is suggested. The probability that Seralini et al's results are significant is sufficient to justify further study.

A challenge to scientific integrity: a critique of the critics of the GMO rat study conducted by Gilles-Eric Séralini et al. (2012)