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Background  Migraine is a common neurovascular condition that may be linked to hyperhomocysteinemia. We have previously provided evidence that reduction of homocysteine with a vitamin supplementation can reduce the occurrence of migraine in women. The current study examined the occurrence of migraine in response to vitamin supplementation with a lower dose of folic acid.    Methods  This was a 6 month randomised, double blinded placebo controlled trial of daily vitamin supplementation containing 1 mg of folic acid, 25 mg of Vitamin B 6  and Vitamin B 12,  on reduction of homocysteine and the occurrence of migraine in 300 female patients diagnosed with migraine with aura.    Results  Vitamin supplementation with 1 mg of folic acid, did not significantly decrease homocysteine levels ( P  = 0.2). The treatment group did not show a significant decrease in the percentage of participants with high migraine disability, severity or frequency at the end of the 6 month intervention ( P  > 0.1).    Conclusion  1 mg of folic acid in combination with vitamin B 6  and B 12  is less effective in reducing migraine associated symptoms compared to the previously tested dosage of 2 mg folic acid in combination with 25 mg of vitamin B 6  and 400 μg of vitamin B 12.

The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients