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Background   GINS4 , an indispensable component of the GINS complex, is vital for a variety of cancer. However, no known empirical research has focused on exploring relationships between  GINS4  and glioma. Thus, this study aims to understand and explain the role of  GINS4  in glioma.    Method  First, we used the data in the CGGA, TCGA, GEO, GEPIA, and HPA databases to explore the expression level of  GINS4  in glioma, the correlation between  GINS4  expression and the clinical features of glioma, its impact on the survival of glioma patients, and verified the analysis results through RT-qPCR, IHC, and meta-analysis. Subsequently, GSEA enrichment analysis is used to find the potential molecular mechanism of  GINS4  to promote the malignant process of glioma and the anti-glioma drugs that may target  GINS4  screened by CMap analysis. Moreover, we further explored the influence of the  GINS4  expression on the immune microenvironment of glioma patients through the TIMER database.    Results  Our results suggested that  GINS4  was elevated in glioma, and the overexpression of  GINS4  was connected with a vast number of clinical features. The next,  GINS4  as an independent prognostic factor, which can result in an unfavorable prognosis of glioma. Once more,  GINS4  may be participating in the oncogenesis of glioma through JAK-STAT signaling pathways, etc. 6-thioguanine, Doxazosin, and Emetine had potential value in the clinical application of drugs targeting  GINS4 . Finally, the expression exhibited a close relationship with some immune cells, especially Dendritic cells.    Conclusion   GINS4  is an independent prognostic factor that led to a poor prognosis of glioma. The present study revealed the probable underlying molecular mechanisms of  GINS4  in glioma and provided a potential target for improving the prognosis of glioma.    Supplementary Information  The online version contains supplementary material available at 10.1186/s10020-021-00378-0.

Overexpression of GINS4 is associated with poor prognosis and survival in glioma patients