English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background: Transposed elements (TEs) have a substantial impact on mammalianevolution and are involved in numerous genetic diseases. We compared the impactof TEs on the human transcriptome and the mouse transcriptome. Results: Wecompiled a dataset of all TEs in the human and mouse genomes, identifying3,932,058 and 3,122,416 TEs, respectively. We than extracted TEs located withinhuman and mouse genes and, surprisingly, we found that 60% of TEs in both humanand mouse are located in intronic sequences, even though introns comprise only24% of the human genome. All TE families in both human and mouse can exonize.TE families that are shared between human and mouse exhibit the same percentageof TE exonization in the two species, but the exonization level of Alu, aprimatespecific retroelement, is significantly greater than that of other TEswithin the human genome, leading to a higher level of TE exonization in humanthan in mouse (1,824 exons compared with 506 exons, respectively). We detecteda primate-specific mechanism for intron gain, in which Alu insertion into anexon creates a new intron located in the 3' untranslated region (termed'intronization'). Finally, the insertion of TEs into the first and last exonsof a gene is more frequent in human than in mouse, leading to longer exons inhuman. Conclusion: Our findings reveal many effects of TEs on these twotranscriptomes. These effects are substantially greater in human than in mouse,which is due to the presence of Alu elements in human.

Comparative analysis of transposed element insertion within human and mouse genomes reveals Alu's unique role in shaping the human transcriptome