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Microarray and RNAi technologies were applied to dissect a transcriptional network induced by DNA damage in human cells, revealing that two pivotal stress-induced transcription factors (NFκB and p53) mediated most of the damage-induced gene activation while a major transducer of the cellular responses to double strand breaks (ATM) was required for the activation of both pathways.

Dissection of a DNA-damage-induced transcriptional network using a combination of microarrays, RNA interference and computational promoter analysis.