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It has been postulated that genetic predisposition may influence the susceptibility to infection and disease outcome. The D allele of the angiotensin-converting enzyme (ACE) gene is associated with many diseases. However, there are only few reports available about infection. We have investigated the association between ACE I/D polymorphism and sepsis, its clinical features such as shock, acute respiratory distress syndrome (ARDS), multiorgan dysfunction syndrome (MODS) and mortality.

Relationship between angiotensin-converting enzyme gene polymorphism (insertion/deletion) and the clinical condition of sepsis