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Introduction  The objective was to study the effects of a lung recruitment procedure by stepwise increases of mean airway pressure upon organ blood flow and hemodynamics during high-frequency oscillatory ventilation (HFOV) versus pressure-controlled ventilation (PCV) in experimental lung injury.    Methods  Lung damage was induced by repeated lung lavages in seven anesthetized pigs (23–26 kg). In randomized order, HFOV and PCV were performed with a fixed sequence of mean airway pressure increases (20, 25, and 30 mbar every 30 minutes). The transpulmonary pressure, systemic hemodynamics, intracranial pressure, cerebral perfusion pressure, organ blood flow (fluorescent microspheres), arterial and mixed venous blood gases, and calculated pulmonary shunt were determined at each mean airway pressure setting.    Results  The transpulmonary pressure increased during lung recruitment (HFOV, from 15 ± 3 mbar to 22 ± 2 mbar,  P  < 0.05; PCV, from 15 ± 3 mbar to 23 ± 2 mbar,  P  < 0.05), and high airway pressures resulted in elevated left ventricular end-diastolic pressure (HFOV, from 3 ± 1 mmHg to 6 ± 3 mmHg,  P  < 0.05; PCV, from 2 ± 1 mmHg to 7 ± 3 mmHg,  P  < 0.05), pulmonary artery occlusion pressure (HFOV, from 12 ± 2 mmHg to 16 ± 2 mmHg,  P  < 0.05; PCV, from 13 ± 2 mmHg to 15 ± 2 mmHg,  P  < 0.05), and intracranial pressure (HFOV, from 14 ± 2 mmHg to 16 ± 2 mmHg,  P  < 0.05; PCV, from 15 ± 3 mmHg to 17 ± 2 mmHg,  P  < 0.05). Simultaneously, the mean arterial pressure (HFOV, from 89 ± 7 mmHg to 79 ± 9 mmHg,  P  < 0.05; PCV, from 91 ± 8 mmHg to 81 ± 8 mmHg,  P  < 0.05), cardiac output (HFOV, from 3.9 ± 0.4 l/minute to 3.5 ± 0.3 l/minute,  P  < 0.05; PCV, from 3.8 ± 0.6 l/minute to 3.4 ± 0.3 l/minute,  P  < 0.05), and stroke volume (HFOV, from 32 ± 7 ml to 28 ± 5 ml,  P  < 0.05; PCV, from 31 ± 2 ml to 26 ± 4 ml,  P  < 0.05) decreased. Blood flows to the heart, brain, kidneys and jejunum were maintained. Oxygenation improved and the pulmonary shunt fraction decreased below 10% (HFOV,  P  < 0.05; PCV,  P  < 0.05). We detected no differences between HFOV and PCV at comparable transpulmonary pressures.    Conclusion  A typical recruitment procedure at the initiation of HFOV improved oxygenation but also decreased systemic hemodynamics at high transpulmonary pressures when no changes of vasoactive drugs and fluid management were performed. Blood flow to the organs was not affected during lung recruitment. These effects were independent of the ventilator mode applied.

Effect of a lung recruitment maneuver by high-frequency oscillatory ventilation in experimental acute lung injury on organ blood flow in pigs.