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Intervention: Patients were randomly assigned to either standard care (n=199) or PCT-guided treatment (n=124). In the latter group, serum PCT concentrations were used to advise clinicians. Use of antibiotics was: strongly discouraged (PCT <0.1 μg/L), discouraged (≥0.1 and <0.25 μg/L), advised (≥0.25 and <0.5 μg/L), or strongly advised (≥0.5 μg/L). Re-evaluation was possible after 6-24 hours in both groups.

Procalcitonin testing has the potential to reduce unnecessary antibiotic use in patients with suspected lower respiratory tract infections