English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

It is well established that during mechanical ventilation of patients with acute respiratory distress syndrome cyclic recruitment/derecruitment and overdistension are potentially injurious for lung tissues. We evaluated whether the forced oscillation technique (FOT) could be used to guide the ventilator settings in order to minimize cyclic lung recruitment/derecruitment and cyclic mechanical stress in an experimental model of acute lung injury.    Methods  We studied six pigs in which lung injury was induced by bronchoalveolar lavage. The animals were ventilated with a tidal volume of 6 ml/kg. Forced oscillations at 5 Hz were superimposed on the ventilation waveform. Pressure and flow were measured at the tip and at the inlet of the endotracheal tube respectively. Respiratory system reactance (Xrs) was computed from the pressure and flow signals and expressed in terms of oscillatory elastance (E X5 ). Positive end-expiratory pressure (PEEP) was increased from 0 to 24 cm H 2 O in steps of 4 cm H 2 O and subsequently decreased from 24 to 0 in steps of 2 cm H 2 O. At each PEEP step CT scans and E X5  were assessed at end-expiration and end-inspiration.    Results  During deflation the relationship between both end-expiratory and end-inspiratory E X5  and PEEP was a U-shaped curve with minimum values at PEEP = 13.4 ± 1.0 cm H 2 O (mean ± SD) and 13.0 ± 1.0 cm H 2 O respectively. E X5  was always higher at end-inspiration than at end-expiration, the difference between the average curves being minimal at 12 cm H 2 O. At this PEEP level, CT did not show any substantial sign of intra-tidal recruitment/derecruitment or expiratory lung collapse.    Conclusions  Using FOT it was possible to measure E X5  both at end-expiration and at end-inspiration. The optimal PEEP strategy based on end-expiratory E X5  minimized intra-tidal recruitment/derecruitment as assessed by CT, and the concurrent attenuation of intra-tidal variations of E X5  suggests that it may also minimize tidal mechanical stress.

critical care

Optimizing positive end-expiratory pressure by oscillatory mechanics minimizes tidal recruitment and distension: an experimental study in a lavage model of lung injury