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There is strong evidence that the alpha form of the oestrogen receptor (ERα) mediates the effects of oestradiol (E2) on proliferation of mammary epithelial cells although, paradoxically, it is rarely expressed in proliferating cells [1,2]. In contrast, mammary glands of mice in which the ERβ gene has been deleted develop normally. However, the role of this ER isoform in controlling growth and/or differentiation of the mammary epithelium has yet to be defined. A recent paper by Cheng and colleagues [3] examines the effects of E2, the selective oestrogen receptor modulator tamoxifen (TAM), and a novel ERβ-specific agonist, BAG, on proliferation and steroid receptor expression in the mammary glands of wild type mice and in those in which the ERβ gene has been knocked out (KO).

Complementary yet distinct roles for oestrogen receptor-α and oestrogen receptor-β in mouse mammary epithelial proliferation