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This multicentre randomised controlled trial investigated\udwhether a computed tomography (CT) scan of the axilla could more\udaccurately assess whether the axillary lymph nodes were involved with\udmalignancy in patients with newly diagnosed breast cancer and therefore\udinfluence surgical decision-making with regard to axillary surgery.\udMethods: Patients with newly diagnosed breast cancer (via screening and\udsymptomatic routes) at two NHS Trusts in the North East of England were\udrecruited and randomised in equal numbers. Both groups received routine\uddiagnostic and surgical care (usual care). In addition, one group received a\udCT scan of their axilla on the same side as the breast cancer.\udResults: The study recruited 297 patients, of whom 291 contributed to\udfindings. CT scan-guided care did not result in a change in the need for a\udsecond operation, with about 20% of both groups needing further surgery.\udPatients within the two groups were similar before treatment, had similar\udtypes and grade of cancer, experienced similar pattern complications and\udreported similar experiences of care.\udConclusion: New diagnostic imaging technologies regularly enter NHS\udcentres of excellence as research tools. It is important these are evaluated\udrigorously before becoming routine care. In patients newly diagnosed with\udbreast cancer, CT-augmented diagnosis of cancer in the axilla was not found\udto improve surgical outcomes or patient experience

Multidetector CT Improving Surgical Outcomes in Breast Cancer (MISO BC)