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In breast cancer (BC), several cytogenetic markers are routinely investigated (Her2, progesterone and estrogen receptors) that distribute patients into different diagnostic groups, determine prognosis and predict effectiveness of therapy. Additional genetic markers can improve prediction or prognosis in BC patients. C-MYC and CCND1 gene aberrations frequently found in BC were chosen for this study.

Role of CCND1 and C-MYC oncogenes in metastatic breast cancer patients treated by herceptin