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Suspicious microcalcification is investigated by vacuum-assisted core biopsy. Many patients, in whom malignancy is diagnosed, go on to have breast-conserving surgery where positive resection margins require re-operation. The aim of this study was to determine whether there is an increased risk of positive margins when malignancy is identified in cores without microcalcification.

Malignant microcalcification: prediction of excision margins by separating calcified and noncalcified core biopsies