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Opticin, a novel extracellular matrix glycoprotein, is a major component of the vitreous humour of the eye. The vitreous humour is one of the few tissues in the body that is avascular and virtually acellular, and previous studies have indicated that opticin contributes to the maintenance of this state by inhibition of angiogenesis. The aim of this present study is to investigate the effect and mode of action of opticin in suppressing tumour cell proliferation and migration in vitro in a panel of breast cancer cell lines and to establish its therapeutic efficacy in human breast tumour xenografts in vivo.

Opticin: a potent anti-angiogenic/antiproliferative agent for breast cancer therapy