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Certain rare, familial mutations in the  ATM ,  BRCA1 ,  BRCA2 ,  CHEK2  or  TP53  genes increase susceptibility to breast cancer but it has not, until now, been clear whether common polymorphic variants in the same genes also increase risk.    Methods  We have attempted a comprehensive, single nucleotide polymorphism (SNP)- and haplotype-tagging association study on each of these five genes in up to 4,474 breast cancer cases from the British, East Anglian SEARCH study and 4,560 controls from the EPIC-Norfolk study, using a two-stage study design. Nine tag SNPs were genotyped in  ATM , together with five in  BRCA1 , sixteen in  BRCA2 , ten in  CHEK2  and five in  TP53 , with the aim of tagging all other known, common variants. SNPs generating the common amino acid substitutions were specifically forced into the tagging set for each gene.    Results  No significant breast cancer associations were detected with any individual or combination of tag SNPs.    Conclusion  It is unlikely that there are any other common variants in these genes conferring measurably increased risks of breast cancer in our study population.

Common variants in the ATM, BRCA1, BRCA2, CHEK2 and TP53 cancer susceptibility genes are unlikely to increase breast cancer risk