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Last month our knowledge of genes mutated in breast cancer took a quantum leap, with the publication in the journal Science of the first results of a screen for mutations in the coding sequences of 13,000 genes in human breast cancer samples [1].  Although we believe that breast cancer is caused by alterations to genes, we have very limited knowledge of what genes get altered. It only takes a moment's thought to realise how big a limitation this is: with a catalogue of gene alterations we could classify breast tumours, probably predict their response to therapy, and design new targeted drugs. We would also begin to understand the cell biology of breast cancer – what distinguishes a benign from a malignant breast tumour, which signalling pathways are disturbed, and so on.

A quantum leap in our knowledge of breast cancer mutations