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Two major gout-causing genes have been identified, the urate transport genes  SLC2A9  and  ABCG2 . Variation within the  SLC17A1  locus, which encodes sodium-dependent phosphate transporter 1, a renal transporter of uric acid, has also been associated with serum urate concentration. However, evidence for association with gout is equivocal. We investigated the association of the  SLC17A1  locus with gout in New Zealand sample sets.    Methods  Five variants ( rs1165196, rs1183201, rs9358890, rs3799344, rs12664474 ) were genotyped across a New Zealand sample set totaling 971 cases and 1,742 controls. Cases were ascertained according to American Rheumatism Association criteria. Two population groups were studied: Caucasian and Polynesian.    Results  At  rs1183201  ( SLC17A1 ), evidence for association with gout was observed in both the Caucasian (odds ratio (OR) = 0.67,  P  = 3.0 × 10 -6 ) and Polynesian (OR = 0.74,  P  = 3.0 × 10 -3 ) groups. Meta-analysis confirmed association of  rs1183201  with gout at a genome-wide level of significance (OR = 0.70,  P  = 3.0 × 10 -8 ). Haplotype analysis suggested the presence of a common protective haplotype.    Conclusion  We confirm the  SLC17A1  locus as the third associated with gout at a genome-wide level of significance.

The renal urate transporter SLC17A1 locus: confirmation of association with gout