English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

HLA-B*51  and  HLA-B*52  are two close human leukocyte antigen (HLA) allele groups with minor amino acid differences. However, they are associated with two different vasculitides ( HLA-B*51  in Behçet's disease and  HLA-B*52  in Takayasu's arteritis (TAK)) and with major clinical and immunological differences. In this study, we aimed to screen a large cohort of TAK patients from Turkey for the presence of  HLA-B*51  and  HLA-B*52  as susceptibility and severity factors.    Methods  TAK patients ( n  = 330) followed at a total of 15 centers were included in the study. The mean age of the patients was 37.8 years, and 86% were women. DNA samples from the patients and healthy controls (HC;  n  = 210) were isolated, and the presence of  HLA-B*51  or  HLA-B*52  was screened for by using PCR with sequence-specific primers.    Results  We found a significant association of  HLA-B*52  with TAK (20.9% vs HC = 6.7%,  P  = 0.000, OR = 3.7, 95% CI = 2.02 to 6.77). The distribution of  HLA-B*51  did not differ between TAK patients and HCs (22.7% vs 24.8%, OR = 0.9, 95% CI = 0.60 to 1.34). The presence of  HLA-B*52  decreased in late-onset patients (> 40 years of age; 12.0%,  P  = 0.024, OR = 0.43, 95% CI = 0.20 to 0.91). Patients with angiographic type I disease with limited aortic involvement also had a lower presence of  HLA-B*52  compared to those with all other disease subtypes (13.1% vs 26%,  P  = 0.005, OR = 0.43, 95% CI = 0.23 to 0.78).    Conclusions  In this study, the previously reported association of TAK with  HLA-B*52  in other populations was confirmed in patients from Turkey. The functional relevance of  HLA-B*52  in TAK pathogenesis needs to be explored further.

Takayasu's arteritis is associated with HLA-B*52, but not with HLA-B*51, in Turkey

Takayasu's arteritis is associated with HLA-B52, but not with HLA-B51, in Turkey