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Acid phosphatase locus 1  ( ACP1 ) encodes a low molecular weight phosphotyrosine phosphatase implicated in a number of different biological functions in the cell. The aim of this study was to determine the contribution of  ACP1  polymorphisms to susceptibility to rheumatoid arthritis (RA), as well as the potential contribution of these polymorphisms to the increased risk of cardiovascular disease (CV) observed in RA patients.    Methods  A set of 1,603 Spanish RA patients and 1,877 healthy controls were included in the study. Information related to the presence/absence of CV events was obtained from 1,284 of these participants. All individuals were genotyped for four  ACP1  single-nucleotide polymorphisms (SNPs), rs10167992, rs11553742, rs7576247, and rs3828329, using a predesigned TaqMan SNP genotyping assay. Classical  ACP1  alleles (*A, *B and *C) were imputed with SNP data.    Results  No association between  ACP1  gene polymorphisms and susceptibility to RA was observed. However, when RA patients were stratified according to the presence or absence of CV events, an association between rs11553742*T and CV events was found ( P  = 0.012, odds ratio (OR) = 2.62 (1.24 to 5.53)). Likewise, the ACP1*C allele showed evidence of association with CV events in patients with RA ( P  = 0.024, OR = 2.43).    Conclusions  Our data show that the ACP1*C allele influences the risk of CV events in patients with RA.

Association of acid phosphatase locus 1*C allele with the risk of cardiovascular events in rheumatoid arthritis patients