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In this paper, it has been experimentally proved for the first time that urate is present in human serum bound to proteins. The protein-bound urates, when liberated, absorb in the ultraviolet light at wavelengths shorter than 293 - 295 nm, the wavelength at which the pure uric acid solution gives his maximum peak [1] . Furthermore; the presence of other protein-bound substances which after being free, give rise to an increase in the absorption spectrum in the region between 270 and 300 nm and not attacked by uricase has been established.

A new concept for Urate in human serum: Evidences that support the existence of Urate as loosely associated and protein-bound Urate in human serum